Where healthcare, hospitality, and lifestyle meet: Hilton opens doors in Jacksonville and redefines Florida travel experiences

(NEWS) JACKSONVILLE, FL, 2025-Oct-3 — /Travel PR News/ — Hilton has officially opened the Hilton Jacksonville at Mayo Clinic, marking the first full-service hotel to debut in Jacksonville in nearly two decades and underscoring Hilton’s ongoing expansion across Florida. Located on the Mayo Clinic campus, the eight-story, 252-room hotel introduces a new chapter of hospitality for Northeast Florida, combining Hilton’s global standards with the welcoming spirit of Jacksonville’s coastal community.

The property represents one of Hilton Hotels & Resorts’ latest showcases of its refreshed brand identity, featuring elevated design and reimagined service touchpoints. Managed by Concord Hospitality, the hotel was developed in close collaboration with Mayo Clinic and Whitman Peterson, with the intent of bridging advanced medical care with world-class hospitality. General Manager Jayson Zimmer emphasized the property’s role as “a haven for guests at pivotal moments in their lives,” whether supporting loved ones, celebrating milestones, or simply enjoying the beauty of Northeast Florida.

The debut of Hilton Jacksonville at Mayo Clinic follows a year of significant growth for Hilton in Florida’s hospitality landscape. In May 2025, Hilton unveiled Beach House Fort Lauderdale, a Hilton Resort, after a multimillion-dollar transformation of the former Hilton Fort Lauderdale Beach Resort, Based on a press update shared by TravelPRNews.com. That property introduced a reimagined beachfront retreat with refreshed accommodations, wellness offerings like the Q Spa, and new dining venues including the chic rooftop restaurant Nubé, creating a coastal haven that blends sophistication with the laid-back energy of South Florida.

Similarly, Hilton further strengthened its Florida presence in September 2025 with the announcement that Sunseeker Resort Florida Gulf Coast joined its Curio Collection by Hilton, elevating the Charlotte Harbor destination into one of the region’s premier waterfront resorts, according to recent coverage on TravelPRNews.com. With 785 rooms, 189 expansive Sunsuites™, more than a dozen dining venues, a championship golf course, and the award-winning Lorelei Spa, the resort exemplifies Hilton’s strategy of pairing lifestyle-focused design with large-scale amenities that serve both leisure and business travelers.

At Hilton Jacksonville at Mayo Clinic, guests can expect a full-service experience with 21,000 square feet of event space, a resort-style heated pool, a 24-hour fitness center, and a lobby coffee shop serving local fare. The signature restaurant, Coastal Kitchen, led by Executive Chef Andrew Kallsnick, offers a wellness-inspired menu that celebrates the flavors of Northeast Florida, from Mayport Shrimp Rolls and Achiote Mahi Tacos to Florida Key Lime Pie.

Designed by DLR Group, the hotel’s architecture mirrors its surroundings, with warm textures, glass accents, and modern lines that create a refined but serene atmosphere. Together with Hilton’s other high-profile Florida openings this year, Hilton Jacksonville at Mayo Clinic underscores the brand’s growth momentum in the state, reaffirming its role in shaping Florida’s luxury and lifestyle hotel landscape while providing meaningful, community-focused hospitality.